Hydrolyzed Collagen Peptides Type I and III are the main structural components of your dog's skin. Type I rebuilds the protective barrier that keeps allergens and bacteria out. Type III repairs damaged tissue in red, irritated, and scratched areas. Together, they provide the essential building blocks for strong, resilient skin.

Collagen makes up up to 90% of the skin's connective tissue. In dogs with chronic dermatitis, natural production decreases with age, making the skin barrier permeable to allergens and bacteria. The low molecular weight hydrolyzed peptides in our liquid formula allow up to 95% absorption, reaching the deep skin layers where true repair happens.

UC-II® is a patented form of undenatured Type II collagen. Unlike standard collagen supplements, it acts directly on the immune system to reduce systemic inflammation that drives constant itching. It is clinically studied to calm inflammatory pathways throughout the body, providing relief without suppressing natural defenses.

Clinical studies show that UC-II® works through a process called oral tolerance, re-educating the overactive immune system that causes chronic itching and skin inflammation. Unlike drugs such as Apoquel that suppress the immune response, UC-II® naturally modulates it, allowing the body to react appropriately without side effects.

Quercetin is a naturally occurring flavonoid with powerful antihistamine properties. It blocks the release of histamine from cells, calming allergic reactions at the source — without the risks of chemical drugs. It is often called nature's Apoquel for its ability to naturally reduce itching and irritation.

When an allergen penetrates the skin, immune cells release histamine, triggering itching, redness, and swelling. Quercetin stabilizes the membranes of histamine-producing cells, preventing excessive release. Unlike chemical antihistamines that block the signal after release, Quercetin acts upstream — stopping the reaction before it starts. This makes it especially effective in combination with collagen: while collagen rebuilds the barrier, Quercetin calms ongoing reactions.

Bromelain is a natural enzyme extracted from pineapple stems. It plays two critical roles in our formula: first, it dramatically boosts the absorption of Quercetin, ensuring the active dose actually reaches your dog's system instead of being wasted. Second, it has its own anti-inflammatory action, calming irritated skin and reducing swelling from within.

Quercetin on its own has notoriously poor bioavailability — much of it passes through the digestive system unabsorbed. Bromelain solves this problem by breaking down proteins and enhancing intestinal absorption, multiplying Quercetin's effectiveness. This is the classic synergy used in human nutraceutical formulations, now adapted for dogs with chronic skin issues.

DHA and EPA Omega-3 fatty acids are powerful natural anti-inflammatories. They calm skin irritation from within, support skin hydration, and promote a shiny, healthy coat. They work in synergy with collagen: while collagen rebuilds the structure, Omega-3s calm the inflammation that damages it.

Chronic inflammation is the silent enemy of the skin barrier. EPA and DHA Omega-3s are incorporated into skin cell membranes, where they produce anti-inflammatory molecules called resolvins and protectins. These molecules actively extinguish inflammation, allowing the skin to heal instead of remaining in a state of perpetual irritation. Less inflamed skin is skin that repairs faster.

Colostrum is the first nourishment produced by mammalian mothers after birth, rich in immunoglobulins and growth factors. It strengthens the dog's natural immunity and repairs the intestinal lining. This is critical because 70% of immune function resides in the gut — a healthy gut means skin that reacts less to allergens.

There is a direct connection between gut health and skin health, called the gut-skin axis. When the intestinal wall is compromised, inflammatory molecules enter the bloodstream and reach the skin, worsening itching and dermatitis. Colostrum contains IgA immunoglobulins and growth factors that repair the intestinal mucosa, reducing permeability and calming the overactive immune response that manifests as chronic itching.

MSM (Methylsulfonylmethane) is a natural source of organic sulfur, a mineral essential for collagen and keratin production. It has powerful anti-inflammatory properties that reduce itching and discomfort, providing fast relief while collagen works to rebuild the skin barrier over time.

Sulfur is the third most abundant mineral in a dog's body and an indispensable cofactor in collagen and keratin synthesis. Without sufficient sulfur, the body cannot effectively build new connective tissue. MSM provides bioavailable sulfur while simultaneously inhibiting pro-inflammatory cytokines — offering a dual mechanism: raw material for reconstruction and inflammation relief during the process.

Astragalus is an adaptogen used for millennia in traditional medicine for its immune-boosting properties. It helps the dog's body modulate the immune response — not suppressing it like drugs do, but teaching it to react proportionately to allergens, without triggering excessive reactions.

In dogs with atopic dermatitis, the immune system is in a state of hyperreactivity: it responds disproportionately to stimuli that should not be threatening (pollen, dust mites, grass). Astragalus contains polysaccharides and saponins that modulate T-lymphocyte activity, rebalancing the immune response. The result: the body stops attacking its own skin and begins to cooperate with the barrier repair process.

Vitamin C is an essential cofactor for collagen production in the dog's body. Without Vitamin C, the body cannot effectively convert collagen peptides into new skin tissue. It is the catalyst that turns the building blocks (collagen) into a solid wall (functional skin barrier).

Vitamin C is indispensable for the hydroxylation of proline and lysine — the two chemical reactions that stabilize the collagen triple helix. Without this stabilization, the collagen produced would be weak and unstable. In addition, Vitamin C is a powerful antioxidant that protects existing collagen from degradation caused by free radicals generated by chronic inflammation.

Zinc is an essential mineral for wound healing and collagen synthesis. It accelerates healing in areas damaged by scratching — sores, hot spots, red areas — and supports skin barrier regeneration. It is particularly important in dogs with chronic lesions that struggle to heal.

Zinc is involved in over 300 enzymatic reactions in the body, many related to tissue repair. It activates matrix metalloproteinases — enzymes that remove damaged tissue to make way for reconstruction — and stimulates keratinocyte proliferation, the cells that form the outer protective layer of skin. A zinc deficiency drastically slows skin healing.

Biotin (Vitamin B7) is essential for coat and skin health. It nourishes hair follicles from the root, reducing shedding and promoting regrowth in areas thinned out by chronic scratching. A healthy, shiny coat is the visible sign of skin that is on the mend.

Biotin is a cofactor in keratin production, the structural protein that makes up hair, nails, and the skin's outer layer. In dogs with chronic dermatitis, constant inflammation depletes Biotin reserves, leading to dull, brittle, and thinning coat. Supplementation restores the reserves needed for healthy keratin production, visible as a thicker, shinier, stronger coat.

Vitamin E is a powerful fat-soluble antioxidant that protects skin cell membranes from damage caused by free radicals. Chronic inflammation generates an excess of free radicals that degrade collagen and slow healing — Vitamin E neutralizes these radicals, protecting the reconstruction work.

Free radicals generated by chronic inflammation attack collagen bonds, accelerating their degradation. Vitamin E incorporates into skin cell membranes where it intercepts free radicals before they can cause damage. This protective effect is synergistic with Vitamin C: while Vitamin C stimulates new collagen production, Vitamin E protects both existing collagen and newly formed collagen from oxidative destruction.

Hyaluronic acid is a molecule naturally present in the skin that can hold up to 1,000 times its weight in water. It keeps the skin hydrated, elastic, and protected. Dry skin cracks and heals more slowly — hyaluronic acid accelerates the repair process by maintaining the optimal skin environment for regeneration.

A dehydrated skin barrier develops micro-cracks that allow allergens and bacteria to enter, triggering inflammation and itching. Hyaluronic acid, supplemented from within, reaches the deep skin layers where it retains the moisture needed to keep the barrier intact and functional. Well-hydrated skin is skin that defends itself better.